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TitleNovel Anti-LY6G6D/CD3 T-Cell-Dependent Bispecific Antibody for the Treatment of Colorectal Cancer.
Journal, issue, pagesMol. Cancer Ther., Vol. 21, Page 974-985, Year 2022
Publish dateSep 8, 2021 (structure data deposition date)
AuthorsWang, P. / Sun, L.L. / Clark, R. / Hristopoulos, M. / Chiu, C.P.C. / Dillon, M. / Lin, W. / Lo, A.A. / Chalsani, S. / Das Thakur, M. ...Wang, P. / Sun, L.L. / Clark, R. / Hristopoulos, M. / Chiu, C.P.C. / Dillon, M. / Lin, W. / Lo, A.A. / Chalsani, S. / Das Thakur, M. / Zimmerman Savill, K.M. / Rouge, L. / Lupardus, P. / Piskol, R. / Husain, B. / Ellerman, D. / Shivva, V. / Leong, S.R. / Ovacik, M. / Totpal, K. / Wu, Y. / Spiess, C. / Lee, G. / Leipold, D.D. / Polson, A.G.
External linksMol. Cancer Ther. / PubMed:35364611
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-7s4g:
Fab fragment bound to the Cter peptide of Ly6G6D
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / leukocyte antigen-6

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