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TitleThe structure of erastin-bound xCT-4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis.
Journal, issue, pagesCell Res, Vol. 32, Issue 7, Page 687-690, Year 2022
Publish dateMar 29, 2022
AuthorsRenhong Yan / Enjun Xie / Yaning Li / Jin Li / Yuanyuan Zhang / Ximin Chi / Xueping Hu / Lei Xu / Tingjun Hou / Brent R Stockwell / Junxia Min / Qiang Zhou / Fudi Wang /
External linksCell Res / PubMed:35352032 / PubMed Central
MethodsEM (single particle)
Resolution3.4 Å
Structure data

31251

7epz

EMDB-31251, PDB-7epz:
Overall structure of Erastin-bound xCT-4F2hc complex
Method: EM (single particle) / Resolution: 3.4 Å

Chemicals

ChemComp-J9O:
2-[(1S)-1-[4-[2-(4-chloranylphenoxy)ethanoyl]piperazin-1-yl]ethyl]-3-(2-ethoxyphenyl)quinazolin-4-one

ChemComp-PX8:
1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATE

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN

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