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-Structure paper
タイトル | Structure and dynamics of Odinarchaeota tubulin and the implications for eukaryotic microtubule evolution. |
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ジャーナル・号・ページ | Sci Adv, Vol. 8, Issue 12, Page eabm2225, Year 2022 |
掲載日 | 2022年3月25日 |
著者 | Caner Akıl / Samson Ali / Linh T Tran / Jérémie Gaillard / Wenfei Li / Kenichi Hayashida / Mika Hirose / Takayuki Kato / Atsunori Oshima / Kosuke Fujishima / Laurent Blanchoin / Akihiro Narita / Robert C Robinson / |
PubMed 要旨 | Tubulins are critical for the internal organization of eukaryotic cells, and understanding their emergence is an important question in eukaryogenesis. Asgard archaea are the closest known prokaryotic ...Tubulins are critical for the internal organization of eukaryotic cells, and understanding their emergence is an important question in eukaryogenesis. Asgard archaea are the closest known prokaryotic relatives to eukaryotes. Here, we elucidated the apo and nucleotide-bound x-ray structures of an Asgard tubulin from hydrothermal living Odinarchaeota (OdinTubulin). The guanosine 5'-triphosphate (GTP)-bound structure resembles a microtubule protofilament, with GTP bound between subunits, coordinating the "+" end subunit through a network of water molecules and unexpectedly by two cations. A water molecule is located suitable for GTP hydrolysis. Time course crystallography and electron microscopy revealed conformational changes on GTP hydrolysis. OdinTubulin forms tubules at high temperatures, with short curved protofilaments coiling around the tubule circumference, more similar to FtsZ, rather than running parallel to its length, as in microtubules. Thus, OdinTubulin represents an evolutionary stage intermediate between prokaryotic FtsZ and eukaryotic microtubule-forming tubulins. |
リンク | Sci Adv / PubMed:35333570 / PubMed Central |
手法 | EM (らせん対称) / X線回折 |
解像度 | 1.25 - 37.17 Å |
構造データ | EMDB-32629: Structure and dynamics of Odinarchaeota tubulin and the implications for eukaryotic microtubule evolution EMDB-32630: Structure and dynamics of Odinarchaeota tubulin and the implications for eukaryotic microtubule evolution PDB-7evb: PDB-7evc: PDB-7evd: PDB-7eve: PDB-7evg: PDB-7evh: PDB-7evi: PDB-7evk: PDB-7evl: PDB-7f1a: PDB-7f1b: |
化合物 | ChemComp-GTP: ChemComp-GDP: ChemComp-NA: ChemComp-HOH: ChemComp-PO4: ChemComp-MG: ChemComp-K: |
由来 |
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キーワード | STRUCTURAL PROTEIN / Asgard / tubulin / GTP / filament |