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TitleA Multispecific Anti-CD40 DARPin Construct Induces Tumor-Selective CD40 Activation and Tumor Regression.
Journal, issue, pagesCancer Immunol Res, Vol. 10, Page 626-640, Year 2022
Publish dateJul 7, 2021 (structure data deposition date)
AuthorsRigamonti, N. / Veitonmaki, N. / Domke, C. / Barsin, S. / Jetzer, S. / Abdelmotaleb, O. / Bessey, R. / Lekishvili, T. / Malvezzi, F. / Gachechiladze, M. ...Rigamonti, N. / Veitonmaki, N. / Domke, C. / Barsin, S. / Jetzer, S. / Abdelmotaleb, O. / Bessey, R. / Lekishvili, T. / Malvezzi, F. / Gachechiladze, M. / Behe, M. / Levitsky, V. / Trail, P.A.
External linksCancer Immunol Res / PubMed:35319751
MethodsX-ray diffraction
Resolution2.29 Å
Structure data

PDB-7p3i:
Crystal structure of human CD40/TNFRSF5 in complex with the anti-CD40 DARPin protein
Method: X-RAY DIFFRACTION / Resolution: 2.29 Å

Chemicals

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsUNKNOWN FUNCTION / TNFRSF5 / immune-oncology / CD40

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