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TitleSHP2 allosteric inhibitor TK-453 alleviates psoriasis-like skin inflammation in mice via inhibition of IL-23/Th17 axis.
Journal, issue, pagesIscience, Vol. 25, Page 104009-104009, Year 2022
Publish dateNov 12, 2021 (structure data deposition date)
AuthorsWang, M. / Li, T. / Ouyang, Z. / Tang, K. / Zhu, Y. / Song, C. / Sun, H. / Yu, B. / Ji, X. / Sun, Y.
External linksIscience / PubMed:35310939
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-7vxg:
Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor TK-453
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-83Q:
6-[4-(aminomethyl)-4-methyl-piperidin-1-yl]-3-[2,3-bis(chloranyl)phenyl]sulfanyl-pyrazin-2-amine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsANTITUMOR PROTEIN / Protein tyrosine phosphatase / SHP2 / inhibitor / complex

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