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TitleCharacterization of the modification of Kelch-like ECH-associated protein 1 by different fumarates.
Journal, issue, pagesBiochem. Biophys. Res. Commun., Vol. 605, Page 9-15, Year 2022
Publish dateMar 3, 2022 (structure data deposition date)
AuthorsQu, L. / Guo, M. / Zhang, H. / Chen, X. / Wei, H. / Jiang, L. / Li, J. / Chen, Z. / Dai, S. / Chen, Y.
External linksBiochem. Biophys. Res. Commun. / PubMed:35306364
MethodsX-ray diffraction
Resolution2.96 - 3.209 Å
Structure data

PDB-7x4w:
Crystal structure of Keap1 BTB domain in complex with dimethyl fumarate (DMF)
Method: X-RAY DIFFRACTION / Resolution: 3.209 Å

PDB-7x4x:
BTB domain of KEAP1 in complex with MEF
Method: X-RAY DIFFRACTION / Resolution: 2.96 Å

Chemicals

ChemComp-9HB:
Dimethyl fumarate

ChemComp-9J3:
4-ethoxy-4-oxobutanoic acid

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / KEAP1 / BTB domain / MEF

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