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Structure paper

TitleStructures of the junctophilin/voltage-gated calcium channel interface reveal hot spot for cardiomyopathy mutations.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 119, Page e2120416119-e2120416119, Year 2022
Publish dateAug 19, 2021 (structure data deposition date)
AuthorsYang, Z.F. / Panwar, P. / McFarlane, C.R. / Tuinte, W.E. / Campiglio, M. / Van Petegem, F.
External linksProc. Natl. Acad. Sci. USA / PubMed:35238659
MethodsX-ray diffraction
Resolution1.31 - 2.35 Å
Structure data

PDB-7rw4:
Crystal structure of junctophilin-1
Method: X-RAY DIFFRACTION / Resolution: 1.31 Å

PDB-7rxe:
Crystal structure of junctophilin-2
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

PDB-7rxq:
Crystal structure of junctophilin-2 in complex with a CaV1.1 peptide
Method: X-RAY DIFFRACTION / Resolution: 2.03 Å

Chemicals

ChemComp-ACT:
ACETATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-IPA:
ISOPROPYL ALCOHOL / alkaloid*YM

ChemComp-FLC:
CITRATE ANION

ChemComp-EOH:
ETHANOL

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
  • oryctolagus cuniculus (rabbit)
KeywordsSTRUCTURAL PROTEIN / Muscle / membrane / ion channel / complex

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