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Structure paper

TitleRegulation of GTPase function by autophosphorylation.
Journal, issue, pagesMol. Cell, Vol. 82, Page 950-, Year 2022
Publish dateJul 23, 2020 (structure data deposition date)
AuthorsJohnson, C.W. / Seo, H.S. / Terrell, E.M. / Yang, M.H. / KleinJan, F. / Gebregiworgis, T. / Gasmi-Seabrook, G.M.C. / Geffken, E.A. / Lakhani, J. / Song, K. ...Johnson, C.W. / Seo, H.S. / Terrell, E.M. / Yang, M.H. / KleinJan, F. / Gebregiworgis, T. / Gasmi-Seabrook, G.M.C. / Geffken, E.A. / Lakhani, J. / Song, K. / Bashyal, P. / Popow, O. / Paulo, J.A. / Liu, A. / Mattos, C. / Marshall, C.B. / Ikura, M. / Morrison, D.K. / Dhe-Paganon, S. / Haigis, K.M.
External linksMol. Cell / PubMed:35202574
MethodsX-ray diffraction
Resolution1.51 - 2.322 Å
Structure data

PDB-7jif:
HRAS A59T GppNHp
Method: X-RAY DIFFRACTION / Resolution: 1.757 Å

PDB-7jig:
HRAS A59T GppNHp crystal 2
Method: X-RAY DIFFRACTION / Resolution: 2.322 Å

PDB-7jih:
HRAS A59E GppNHp
Method: X-RAY DIFFRACTION / Resolution: 1.989 Å

PDB-7jii:
HRAS A59E GDP
Method: X-RAY DIFFRACTION / Resolution: 1.532 Å

PDB-7kmr:
Crystal structure analysis of human KRAS mutant
Method: X-RAY DIFFRACTION / Resolution: 1.51 Å

Chemicals

ChemComp-GNP:
PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER / GppNHp, GMPPNP, energy-carrying molecule analogue*YM

ChemComp-MG:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-CA:
Unknown entry

Source
  • homo sapiens (human)
KeywordsONCOPROTEIN / Mutant Cancer GTPase / HYDROLASE / GTPase / Oncogenic

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