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TitleDiscovery of MAP855, an Efficacious and Selective MEK1/2 Inhibitor with an ATP-Competitive Mode of Action.
Journal, issue, pagesJ. Med. Chem., Vol. 65, Page 4350-4366, Year 2022
Publish dateSep 20, 2021 (structure data deposition date)
AuthorsPoddutoori, R. / Aardalen, K. / Aithal, K. / Barahagar, S.S. / Belliappa, C. / Bock, M. / Chelur, S. / Gerken, A. / Gopinath, S. / Gruenenfelder, B. ...Poddutoori, R. / Aardalen, K. / Aithal, K. / Barahagar, S.S. / Belliappa, C. / Bock, M. / Chelur, S. / Gerken, A. / Gopinath, S. / Gruenenfelder, B. / Kiffe, M. / Krishnaswami, M. / Langowski, J. / Madapa, S. / Narayanan, K. / Pandit, C. / Panigrahi, S.K. / Perrone, M. / Potakamuri, R.K. / Ramachandra, M. / Ramanathan, A. / Ramos, R. / Sager, E. / Samajdar, S. / Subramanya, H.S. / Thimmasandra, D.S. / Venetsanakos, E. / Mobitz, H.
External linksJ. Med. Chem. / PubMed:35195996
MethodsX-ray diffraction
Resolution2.13 Å
Structure data

PDB-7pqv:
MEK1 IN COMPLEX WITH COMPOUND 7
Method: X-RAY DIFFRACTION / Resolution: 2.13 Å

Chemicals

ChemComp-80C:
8-(2-chloranyl-4-methoxy-phenyl)-7-fluoranyl-1-piperidin-4-yl-imidazo[4,5-c]quinoline

ChemComp-CA:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / MEK1 MITOGEN-ACTIVATED PROTEIN KINASE 1 / KINASE INHIBITOR / ANTI-CANCER DRUG

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