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TitleDesign, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens.
Journal, issue, pagesJ. Med. Chem., Vol. 65, Page 4481-4495, Year 2022
Publish dateAug 19, 2021 (structure data deposition date)
AuthorsMa, Z. / He, S. / Yuan, Y. / Zhuang, Z. / Liu, Y. / Wang, H. / Chen, J. / Xu, X. / Ding, C. / Molodtsov, V. ...Ma, Z. / He, S. / Yuan, Y. / Zhuang, Z. / Liu, Y. / Wang, H. / Chen, J. / Xu, X. / Ding, C. / Molodtsov, V. / Lin, W. / Robertson, G.T. / Weiss, W.J. / Pulse, M. / Nguyen, P. / Duncan, L. / Doyle, T. / Ebright, R.H. / Lynch, A.S.
External linksJ. Med. Chem. / PubMed:35175750
MethodsX-ray diffraction
Resolution3.7 Å
Structure data

PDB-7rwi:
Mycobacterium tuberculosis RNA polymerase sigma L holoenzyme open promoter complex containing TNP-2198
Method: X-RAY DIFFRACTION / Resolution: 3.7 Å

Chemicals

ChemComp-7US:
(3aM,9S,10bP,14S,15R,16S,17R,18R,19R,20S,21S,25R)-6,18,20-trihydroxy-14-methoxy-7,9,15,17,19,21,25-heptamethyl-1'-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]-5,10,26-trioxo-3,5,9,10-tetrahydrospiro[9,4-(epoxypentadecanoimino)furo[2',3':7,8]naphtho[1,2-d]imidazole-2,4'-piperidin]-16-yl acetate

Source
  • mycobacterium tuberculosis (bacteria)
  • synthetic construct (others)
KeywordsTRANSCRIPTION/INHIBITOR / Mycobacterium tuberculosis / RNA polymerase / transcription inhibitor / TNP-2198 / open promoter complex / TRANSCRIPTION-INHIBITOR complex

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