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TitleDiscovery and Characterization of a Cryptic Secondary Binding Site in the Molecular Chaperone HSP70.
Journal, issue, pagesMolecules, Vol. 27, Year 2022
Publish dateNov 2, 2021 (structure data deposition date)
AuthorsO'Connor, S. / Le Bihan, Y.V. / Westwood, I.M. / Liu, M. / Mak, O.W. / Zazeri, G. / Povinelli, A.P.R. / Jones, A.M. / van Montfort, R. / Reynisson, J. / Collins, I.
External linksMolecules / PubMed:35164081
MethodsX-ray diffraction
Resolution1.79 Å
Structure data

PDB-7q4r:
Crystal structure of human HSP72-NBD in complex with fragment 1
Method: X-RAY DIFFRACTION / Resolution: 1.79 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-8X6:
4-(4-phenyl-1,3-thiazol-2-yl)piperazine-1-carboxamide

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCHAPERONE / Inhibitor / ATPase

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