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TitleTargetable HER3 functions driving tumorigenic signaling in HER2-amplified cancers.
Journal, issue, pagesCell Rep, Vol. 38, Page 110291-110291, Year 2022
Publish dateApr 24, 2019 (structure data deposition date)
AuthorsCampbell, M.R. / Ruiz-Saenz, A. / Peterson, E. / Agnew, C. / Ayaz, P. / Garfinkle, S. / Littlefield, P. / Steri, V. / Oeffinger, J. / Sampang, M. ...Campbell, M.R. / Ruiz-Saenz, A. / Peterson, E. / Agnew, C. / Ayaz, P. / Garfinkle, S. / Littlefield, P. / Steri, V. / Oeffinger, J. / Sampang, M. / Shan, Y. / Shaw, D.E. / Jura, N. / Moasser, M.M.
External linksCell Rep / PubMed:35108525
MethodsX-ray diffraction
Resolution2.501 Å
Structure data

PDB-6op9:
HER3 pseudokinase domain bound to bosutinib
Method: X-RAY DIFFRACTION / Resolution: 2.501 Å

Chemicals

ChemComp-DB8:
4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile / inhibitor, medication*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE inhibitor / RECEPTOR TYROSINE KINASE / PSEUDOKINASE / BOSUTINIB / MEMBRANE / SIGNALING PROTEIN / TRANSFERASE-TRANSFERASE inhibitor complex

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