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Structure paper

TitleStructure and Fc-Effector Function of Rhesusized Variants of Human Anti-HIV-1 IgG1s.
Journal, issue, pagesFront Immunol, Vol. 12, Page 787603-787603, Year 2021
Publish dateMay 26, 2021 (structure data deposition date)
AuthorsTolbert, W.D. / Nguyen, D.N. / Tuyishime, M. / Crowley, A.R. / Chen, Y. / Jha, S. / Goodman, D. / Bekker, V. / Mudrak, S.V. / DeVico, A.L. ...Tolbert, W.D. / Nguyen, D.N. / Tuyishime, M. / Crowley, A.R. / Chen, Y. / Jha, S. / Goodman, D. / Bekker, V. / Mudrak, S.V. / DeVico, A.L. / Lewis, G.K. / Theis, J.F. / Pinter, A. / Moody, M.A. / Easterhoff, D. / Wiehe, K. / Pollara, J. / Saunders, K.O. / Tomaras, G.D. / Ackerman, M. / Ferrari, G. / Pazgier, M.
External linksFront Immunol / PubMed:35069563
MethodsX-ray diffraction
Resolution2 - 2.9 Å
Structure data

PDB-7n0x:
Rhesusized RV144 DH827 Fab bound to HIV-1 Env V2 peptide
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-7n8q:
Rhesusized RV305 DH677.3 Fab bound to Clade A/E 93TH057 HIV-1 gp120 core.
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-HOH:
WATER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • macaca mulatta (Rhesus monkey)
  • human immunodeficiency virus 1
  • synthetic construct (others)
KeywordsIMMUNE SYSTEM / DH827 / HIV-1 Env V2 peptide / RV144 / Rhesusized antibody / DH677.3 / RV305

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