タイトル | Structural basis for substrate binding and catalysis by a self-alkylating ribozyme. |
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ジャーナル・号・ページ | Nat. Chem. Biol., Vol. 18, Page 376-384, Year 2022 |
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掲載日 | 2020年6月24日 (構造データの登録日) |
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著者 | Krochmal, D. / Shao, Y. / Li, N.S. / DasGupta, S. / Shelke, S.A. / Koirala, D. / Piccirilli, J.A. |
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リンク | Nat. Chem. Biol. / PubMed:35058645 |
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手法 | X線回折 |
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解像度 | 1.708 - 2.488 Å |
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構造データ | PDB-6xjq: Crystal structure of a self-alkylating ribozyme - alkylated form with biotinylated epoxide substrate 手法: X-RAY DIFFRACTION / 解像度: 1.708 Å PDB-6xjw: Crystal structure of a self-alkylating ribozyme - alkylated form without biotin moiety 手法: X-RAY DIFFRACTION / 解像度: 1.918 Å PDB-6xjy: Crystal structure of a self-alkylating ribozyme - short time incubation with the epoxide substrate 手法: X-RAY DIFFRACTION / 解像度: 2.156 Å PDB-6xjz: Crystal structure of a self-alkylating ribozyme - apo form 手法: X-RAY DIFFRACTION / 解像度: 2.488 Å |
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化合物 | ChemComp-V4J: 2-{[(4R)-4-hydroxyhexyl]oxy}ethyl 5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoate
ChemComp-97C: 2-{[(4R)-4-hydroxyhexyl]oxy}ethyl pentanoate
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由来 | homo sapiens (ヒト)![](img/tx_archaea.gif) ![](data/taxo/icon/Aeropyrum_pernix_K1_S.png) aeropyrum pernix (古細菌)
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キーワード | RNA/IMMUNE SYSTEM / Self-alkylating ribozyme / Antibody-assisted RNA crystallography / RNA catalysis / RNA-Immune System complex |
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