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Structure paper

TitleStructural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors.
Journal, issue, pagesNat Commun, Vol. 13, Page 19-19, Year 2022
Publish dateMay 27, 2021 (structure data deposition date)
AuthorsWu, D. / Kolesnikov, A. / Yin, R. / Guest, J.D. / Gowthaman, R. / Shmelev, A. / Serdyuk, Y. / Dianov, D.V. / Efimov, G.A. / Pierce, B.G. / Mariuzza, R.A.
External linksNat Commun / PubMed:35013235
MethodsX-ray diffraction
Resolution1.881 - 2.81 Å
Structure data

PDB-7n1a:
SARS-CoV-2 YLQ peptide binds to HLA-A2
Method: X-RAY DIFFRACTION / Resolution: 2.065 Å

PDB-7n1b:
SARS-CoV-2 RLQ peptide binds to HLA-A2
Method: X-RAY DIFFRACTION / Resolution: 2.81 Å

PDB-7n1c:
SARS-CoV-2 RLQ peptide-specific TCR pRLQ3
Method: X-RAY DIFFRACTION / Resolution: 1.881 Å

PDB-7n1d:
SARS-CoV-2 YLQ peptide-specific TCR pYLQ7
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

PDB-7n1e:
SARS-CoV-2 RLQ peptide-specific TCR pRLQ3 binds to RLQ-HLA-A2
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-7n1f:
SARS-CoV-2 YLQ peptide-specific TCR pYLQ7 binds to YLQ-HLA-A2
Method: X-RAY DIFFRACTION / Resolution: 2.393 Å

Chemicals

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • severe acute respiratory syndrome coronavirus 2
KeywordsIMMUNE SYSTEM / pMHC / SARS-CoV-2 / SPIKE / YLQ / RLQ / TCR / TCR-pMHC

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