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TitleInhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment.
Journal, issue, pagesMol. Ther., Vol. 30, Page 1484-1499, Year 2022
Publish dateNov 25, 2021 (structure data deposition date)
AuthorsDanis, C. / Dupre, E. / Zejneli, O. / Caillierez, R. / Arrial, A. / Begard, S. / Mortelecque, J. / Eddarkaoui, S. / Loyens, A. / Cantrelle, F.X. ...Danis, C. / Dupre, E. / Zejneli, O. / Caillierez, R. / Arrial, A. / Begard, S. / Mortelecque, J. / Eddarkaoui, S. / Loyens, A. / Cantrelle, F.X. / Hanoulle, X. / Rain, J.C. / Colin, M. / Buee, L. / Landrieu, I.
External linksMol. Ther. / PubMed:35007758
MethodsX-ray diffraction
Resolution1.7 Å
Structure data

PDB-7qcq:
VHH Z70 in interaction with PHF6 Tau peptide
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • lama glama (llama)
KeywordsIMMUNE SYSTEM / Nanobody / VHH / Tau / PHF6

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