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Title | Design, Synthesis, and Characterization of I-BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate. |
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Journal, issue, pages | J. Med. Chem., Vol. 65, Page 2262-2287, Year 2022 |
Publish date | Nov 27, 2021 (structure data deposition date) |
Authors | Humphreys, P.G. / Atkinson, S.J. / Bamborough, P. / Bit, R.A. / Chung, C.W. / Craggs, P.D. / Cutler, L. / Davis, R. / Ferrie, A. / Gong, G. ...Humphreys, P.G. / Atkinson, S.J. / Bamborough, P. / Bit, R.A. / Chung, C.W. / Craggs, P.D. / Cutler, L. / Davis, R. / Ferrie, A. / Gong, G. / Gordon, L.J. / Gray, M. / Harrison, L.A. / Hayhow, T.G. / Haynes, A. / Henley, N. / Hirst, D.J. / Holyer, I.D. / Lindon, M.J. / Lovatt, C. / Lugo, D. / McCleary, S. / Molnar, J. / Osmani, Q. / Patten, C. / Preston, A. / Rioja, I. / Seal, J.T. / Smithers, N. / Sun, F. / Tang, D. / Taylor, S. / Theodoulou, N.H. / Thomas, C. / Watson, R.J. / Wellaway, C.R. / Zhu, L. / Tomkinson, N.C.O. / Prinjha, R.K. |
External links | J. Med. Chem. / PubMed:34995458 |
Methods | X-ray diffraction |
Resolution | 1.67 Å |
Structure data | PDB-7qdl: |
Chemicals | ChemComp-AKQ: ChemComp-EDO: ChemComp-HOH: |
Source |
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Keywords | TRANSCRIPTION / INHIBITOR / HISTONE / EPIGENETIC READER / BROMODOMAIN / BRD4 / BROMODOMAIN CONTAINING PROTEIN 4 / ANTAGONIST |