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TitleA novel hotspot of gelsolin instability triggers an alternative mechanism of amyloid aggregation.
Journal, issue, pagesComput Struct Biotechnol J, Vol. 19, Page 6355-6365, Year 2021
Publish dateJul 5, 2021 (structure data deposition date)
AuthorsBollati, M. / Diomede, L. / Giorgino, T. / Natale, C. / Fagnani, E. / Boniardi, I. / Barbiroli, A. / Alemani, R. / Beeg, M. / Gobbi, M. ...Bollati, M. / Diomede, L. / Giorgino, T. / Natale, C. / Fagnani, E. / Boniardi, I. / Barbiroli, A. / Alemani, R. / Beeg, M. / Gobbi, M. / Fakin, A. / Mastrangelo, E. / Milani, M. / Presciuttini, G. / Gabellieri, E. / Cioni, P. / de Rosa, M.
External linksComput Struct Biotechnol J / PubMed:34938411
MethodsX-ray diffraction
Resolution3 Å
Structure data

PDB-7p2b:
Crystal structure of human gelsolin amyloid mutant A551P
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSTRUCTURAL PROTEIN / Gelsolin protein / actin binding protein

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