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-Structure paper
Title | Rational Design of Highly Potent, Selective, and Bioavailable SGK1 Protein Kinase Inhibitors for the Treatment of Osteoarthritis. |
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Journal, issue, pages | J. Med. Chem., Vol. 65, Page 1567-1584, Year 2022 |
Publish date | Sep 29, 2021 (structure data deposition date) |
![]() | Halland, N. / Schmidt, F. / Weiss, T. / Li, Z. / Czech, J. / Saas, J. / Ding-Pfennigdorff, D. / Dreyer, M.K. / Strubing, C. / Nazare, M. |
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Methods | X-ray diffraction |
Resolution | 2.506 Å |
Structure data | ![]() PDB-7pue: |
Chemicals | ![]() ChemComp-GOL: ![]() ChemComp-86H: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSFERASE / serine/threonine protein kinase / atp-competitive inhibitor / DFG-loop / hinge-binder / osteoarthritis / cartilage degradation / pyrazolo-pyridine |