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-Structure paper
Title | Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism. |
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Journal, issue, pages | J. Med. Chem., Vol. 65, Page 633-664, Year 2022 |
Publish date | Nov 7, 2021 (structure data deposition date) |
![]() | Wellaway, C.R. / Baldwin, I.R. / Bamborough, P. / Barker, D. / Bartholomew, M.A. / Chung, C.W. / Dumpelfeld, B. / Evans, J.P. / Fazakerley, N.J. / Homes, P. ...Wellaway, C.R. / Baldwin, I.R. / Bamborough, P. / Barker, D. / Bartholomew, M.A. / Chung, C.W. / Dumpelfeld, B. / Evans, J.P. / Fazakerley, N.J. / Homes, P. / Keeling, S.P. / Lewell, X.Q. / McNab, F.W. / Morley, J. / Needham, D. / Neu, M. / van Oosterhout, A.J.M. / Pal, A. / Reinhard, F.B.M. / Rianjongdee, F. / Robertson, C.M. / Rowland, P. / Shah, R.R. / Sherriff, E.B. / Sloan, L.A. / Teague, S. / Thomas, D.A. / Wellaway, N. / Wojno-Picon, J. / Woolven, J.M. / Coe, D.M. |
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Methods | X-ray diffraction |
Resolution | 1.61 - 1.97 Å |
Structure data | ![]() PDB-7q6h: ![]() PDB-7q7i: ![]() PDB-7q7k: ![]() PDB-7q7l: ![]() PDB-7q7w: |
Chemicals | ![]() ChemComp-934: ![]() ChemComp-SO4: ![]() ChemComp-PHU: ![]() ChemComp-HOH: ![]() ChemComp-9I8: ![]() ChemComp-9I5: ![]() ChemComp-9I2: ![]() ChemComp-GOL: ![]() ChemComp-9HR: |
Source |
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![]() | SIGNALING PROTEIN / INHIBITOR / JAK3 / KINASE / JAK2 / Janus kinase 2 |