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Structure paper

TitleNext generation Fc scaffold for multispecific antibodies.
Journal, issue, pagesIscience, Vol. 24, Page 103447-103447, Year 2021
Publish dateFeb 23, 2021 (structure data deposition date)
AuthorsEstes, B. / Sudom, A. / Gong, D. / Whittington, D.A. / Li, V. / Mohr, C. / Li, D. / Riley, T.P. / Shi, S.D. / Zhang, J. ...Estes, B. / Sudom, A. / Gong, D. / Whittington, D.A. / Li, V. / Mohr, C. / Li, D. / Riley, T.P. / Shi, S.D. / Zhang, J. / Garces, F. / Wang, Z.
External linksIscience / PubMed:34877503
MethodsX-ray diffraction
Resolution1.95 - 2.45 Å
Structure data

PDB-7lur:
Stable Effector Functionless 2 (SEFL2) IgG1 Fc Scaffold Bound to a Minimized Version of the B-domain (Mini-Z) from Protein A Called Z34C
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-7lus:
IgG2 Fc Charge Pair Mutation version 1 (CPMv1)
Method: X-RAY DIFFRACTION / Resolution: 2.45 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • staphylococcus aureus (bacteria)
KeywordsIMMUNE SYSTEM / fragment crystallizable / Fc

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