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TitleStructure-Guided Approach to Relieving Transcriptional Repression in Resistance to Thyroid Hormone alpha.
Journal, issue, pagesMol. Cell. Biol., Vol. 42, Page e0036321-e0036321, Year 2022
Publish dateNov 30, 2021 (structure data deposition date)
AuthorsRomartinez-Alonso, B. / Agostini, M. / Jones, H. / McLellan, J. / Sood, D.E. / Tomkinson, N. / Marelli, F. / Gentile, I. / Visser, W.E. / Schoenmakers, E. ...Romartinez-Alonso, B. / Agostini, M. / Jones, H. / McLellan, J. / Sood, D.E. / Tomkinson, N. / Marelli, F. / Gentile, I. / Visser, W.E. / Schoenmakers, E. / Fairall, L. / Privalsky, M. / Moran, C. / Persani, L. / Chatterjee, K. / Schwabe, J.W.R.
External linksMol. Cell. Biol. / PubMed:34871063
MethodsX-ray diffraction
Resolution3 Å
Structure data

PDB-7qdt:
Crystal structure of a mutant (P393GX) Thyroid Receptor Alpha ligand binding domain designed to model dominant negative human mutations.
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-T3:
3,5,3'TRIIODOTHYRONINE / hormone*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsNUCLEAR PROTEIN / Nuclear receptor / Thyroid hormone / Mutation

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