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Structure paper

TitleThe active site region plays a critical role in Na + binding to thrombin.
Journal, issue, pagesJ. Biol. Chem., Vol. 298, Page 101458-101458, Year 2022
Publish dateNov 8, 2021 (structure data deposition date)
AuthorsPelc, L.A. / Koester, S.K. / Kukla, C.R. / Chen, Z. / Di Cera, E.
External linksJ. Biol. Chem. / PubMed:34861239
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-7sr9:
Human alpha-thrombin with 180- and 220- loops replaced with homologous loops from protein C
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsBLOOD CLOTTING / Thrombin

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