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TitleInhibitors of the Hippo Pathway Kinases STK3/MST2 and STK4/MST1 Have Utility for the Treatment of Acute Myeloid Leukemia.
Journal, issue, pagesJ. Med. Chem., Vol. 65, Page 1352-1369, Year 2022
Publish dateMar 13, 2020 (structure data deposition date)
AuthorsBata, N. / Chaikuad, A. / Bakas, N.A. / Limpert, A.S. / Lambert, L.J. / Sheffler, D.J. / Berger, L.M. / Liu, G. / Yuan, C. / Wang, L. ...Bata, N. / Chaikuad, A. / Bakas, N.A. / Limpert, A.S. / Lambert, L.J. / Sheffler, D.J. / Berger, L.M. / Liu, G. / Yuan, C. / Wang, L. / Peng, Y. / Dong, J. / Celeridad, M. / Layng, F. / Knapp, S. / Cosford, N.D.P.
External linksJ. Med. Chem. / PubMed:34807584
MethodsX-ray diffraction
Resolution2.58 Å
Structure data

PDB-6yat:
Crystal structure of STK4 (MST1) in complex with compound 6
Method: X-RAY DIFFRACTION / Resolution: 2.58 Å

Chemicals

ChemComp-3FX:
(2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid

ChemComp-GOL:
GLYCEROL

ChemComp-OJ5:
4-[5-(3-chlorophenyl)-7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl]morpholine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / kinase / kinase inhibitor / MST1 / STK4 / hippo pathway / chemical probe / Structural Genomics / Structural Genomics Consortium / SGC

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