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TitleImmunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability.
Journal, issue, pagesImmunity, Vol. 54, Page 2908-2921.e6, Year 2021
Publish dateMay 12, 2021 (structure data deposition date)
AuthorsBurnett, D.L. / Jackson, K.J.L. / Langley, D.B. / Aggrawal, A. / Stella, A.O. / Johansen, M.D. / Balachandran, H. / Lenthall, H. / Rouet, R. / Walker, G. ...Burnett, D.L. / Jackson, K.J.L. / Langley, D.B. / Aggrawal, A. / Stella, A.O. / Johansen, M.D. / Balachandran, H. / Lenthall, H. / Rouet, R. / Walker, G. / Saunders, B.M. / Singh, M. / Li, H. / Henry, J.Y. / Jackson, J. / Stewart, A.G. / Witthauer, F. / Spence, M.A. / Hansbro, N.G. / Jackson, C. / Schofield, P. / Milthorpe, C. / Martinello, M. / Schulz, S.R. / Roth, E. / Kelleher, A. / Emery, S. / Britton, W.J. / Rawlinson, W.D. / Karl, R. / Schafer, S. / Winkler, T.H. / Brink, R. / Bull, R.A. / Hansbro, P.M. / Jack, H.M. / Turville, S. / Christ, D. / Goodnow, C.C.
External linksImmunity / PubMed:34788600
MethodsX-ray diffraction
Resolution2.29 Å
Structure data

PDB-7msq:
Complex between the Fab arm of AB-3467 and the SARS-CoV-2 receptor binding domain (RBD)
Method: X-RAY DIFFRACTION / Resolution: 2.29 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-SCN:
THIOCYANATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • severe acute respiratory syndrome coronavirus 2
  • homo sapiens (human)
KeywordsVIRAL PROTEIN/ANTIVIRAL PROTEIN / SARS-CoV-2 receptor binding domain AB-3467 / ANTIVIRAL PROTEIN / VIRAL PROTEIN-ANTIVIRAL PROTEIN complex

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