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TitleDiscovery of a novel pseudo beta-hairpin structure of N-truncated amyloid-beta for use as a vaccine against Alzheimer's disease.
Journal, issue, pagesMol Psychiatry, Vol. 27, Page 840-848, Year 2022
Publish dateJun 16, 2021 (structure data deposition date)
AuthorsBakrania, P. / Hall, G. / Bouter, Y. / Bouter, C. / Beindorff, N. / Cowan, R. / Davies, S. / Price, J. / Mpamhanga, C. / Love, E. ...Bakrania, P. / Hall, G. / Bouter, Y. / Bouter, C. / Beindorff, N. / Cowan, R. / Davies, S. / Price, J. / Mpamhanga, C. / Love, E. / Matthews, D. / Carr, M.D. / Bayer, T.A.
External linksMol Psychiatry / PubMed:34776512
MethodsX-ray diffraction
Resolution1.4 - 2.5 Å
Structure data

PDB-7ow1:
Crystal Structure of TAP01 in complex with amyloid beta peptide
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

PDB-7oxn:
Crystal Structure of TAP01 in complex with cyclised amyloid beta peptide
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-FLC:
CITRATE ANION

ChemComp-HOH:
WATER

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-ZN:
Unknown entry

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Alzheimer's Disease

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