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Structure paper

TitleImproved RAD51 binders through motif shuffling based on the modularity of BRC repeats.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 118, Year 2021
Publish dateSep 25, 2018 (structure data deposition date)
AuthorsLindenburg, L.H. / Pantelejevs, T. / Gielen, F. / Zuazua-Villar, P. / Butz, M. / Rees, E. / Kaminski, C.F. / Downs, J.A. / Hyvonen, M. / Hollfelder, F.
External linksProc. Natl. Acad. Sci. USA / PubMed:34772801
MethodsX-ray diffraction
Resolution1.97 Å
Structure data

PDB-6hqu:
Humanised RadA mutant HumRadA22 in complex with a recombined BRC repeat 8-2
Method: X-RAY DIFFRACTION / Resolution: 1.97 Å

Chemicals

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • pyrococcus furiosus (strain atcc 43587 / dsm 3638 / jcm 8422 / vc1) (archaea)
  • homo sapiens (human)
KeywordsONCOPROTEIN / RadA / Rad51 / BRC repeat / recombinase / ATPase / BRCA2

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