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TitleMitoquinone Inactivates Mitochondrial Chaperone TRAP1 by Blocking the Client Binding Site.
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 143, Page 19684-19696, Year 2021
Publish dateMay 28, 2021 (structure data deposition date)
AuthorsYoon, N.G. / Lee, H. / Kim, S.Y. / Hu, S. / Kim, D. / Yang, S. / Hong, K.B. / Lee, J.H. / Kang, S. / Kim, B.G. ...Yoon, N.G. / Lee, H. / Kim, S.Y. / Hu, S. / Kim, D. / Yang, S. / Hong, K.B. / Lee, J.H. / Kang, S. / Kim, B.G. / Myung, K. / Lee, C. / Kang, B.H.
External linksJ. Am. Chem. Soc. / PubMed:34758612
MethodsX-ray diffraction
Resolution2.297 Å
Structure data

PDB-7exp:
Crystal structure of zebrafish TRAP1 with AMPPNP and MitoQ
Method: X-RAY DIFFRACTION / Resolution: 2.297 Å

Chemicals

ChemComp-ANP:
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP, energy-carrying molecule analogue*YM

ChemComp-MG:
Unknown entry

ChemComp-CO:
Unknown entry

ChemComp-05M:
2,3-dimethoxy-5-methyl-6-[10-(triphenyl-$l^{5}-phosphanyl)decyl]cyclohexa-2,5-diene-1,4-dione

ChemComp-HOH:
WATER

Source
  • danio rerio (zebrafish)
KeywordsCHAPERONE / TRAP1 / HSP90 / Mitoquinone / MitoQ

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