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-Structure paper
Title | Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis. |
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Journal, issue, pages | J. Med. Chem., Vol. 65, Page 1206-1224, Year 2022 |
Publish date | Feb 20, 2021 (structure data deposition date) |
![]() | Hopkins, B.T. / Bame, E. / Bajrami, B. / Black, C. / Bohnert, T. / Boiselle, C. / Burdette, D. / Burns, J.C. / Delva, L. / Donaldson, D. ...Hopkins, B.T. / Bame, E. / Bajrami, B. / Black, C. / Bohnert, T. / Boiselle, C. / Burdette, D. / Burns, J.C. / Delva, L. / Donaldson, D. / Grater, R. / Gu, C. / Hoemberger, M. / Johnson, J. / Kapadnis, S. / King, K. / Lulla, M. / Ma, B. / Marx, I. / Magee, T. / Meissner, R. / Metrick, C.M. / Mingueneau, M. / Murugan, P. / Otipoby, K.L. / Polack, E. / Poreci, U. / Prince, R. / Roach, A.M. / Rowbottom, C. / Santoro, J.C. / Schroeder, P. / Tang, H. / Tien, E. / Zhang, F. / Lyssikatos, J. |
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Methods | X-ray diffraction |
Resolution | 1.53 - 1.69 Å |
Structure data | ![]() PDB-7lty: ![]() PDB-7ltz: |
Chemicals | ![]() ChemComp-YD7: ![]() ChemComp-DMS: ![]() ChemComp-HOH: ![]() ChemComp-YDA: ![]() ChemComp-DTT: ![]() ChemComp-ACT: |
Source |
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![]() | TRANSFERASE/TRANSFERASE INHIBITOR / transferase / transferase inhibitor / kinase / kinase inhibitor / TRANSFERASE-TRANSFERASE INHIBITOR complex |