Movie
Controller
Structure viewers
About Yorodumi Papers
+Search query
-Structure paper
| Title | A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 64, Page 16770-16800, Year 2021 |
| Publish date | Sep 10, 2021 (structure data deposition date) |
 Authors | Tucker, T.J. / Embrey, M.W. / Alleyne, C. / Amin, R.P. / Bass, A. / Bhatt, B. / Bianchi, E. / Branca, D. / Bueters, T. / Buist, N. ...Tucker, T.J. / Embrey, M.W. / Alleyne, C. / Amin, R.P. / Bass, A. / Bhatt, B. / Bianchi, E. / Branca, D. / Bueters, T. / Buist, N. / Ha, S.N. / Hafey, M. / He, H. / Higgins, J. / Johns, D.G. / Kerekes, A.D. / Koeplinger, K.A. / Kuethe, J.T. / Li, N. / Murphy, B. / Orth, P. / Salowe, S. / Shahripour, A. / Tracy, R. / Wang, W. / Wu, C. / Xiong, Y. / Zokian, H.J. / Wood, H.B. / Walji, A. |
 External links | J. Med. Chem. / PubMed:34704436 |
| Methods | X-ray diffraction |
| Resolution | 1.272 - 2.041 Å |
| Structure data |  PDB-7s5g:  PDB-7s5h: |
| Chemicals |  ChemComp-GOL:  ChemComp-89N:  ChemComp-HOH: |
| Source |
|
 Keywords | PROTEIN BINDING / HYDROLASE / cholesterol / LDL receptor / EGFA domain |
homo sapiens (human)