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TitleN -Aromatic-Substituted Indazole Derivatives as Brain-Penetrant and Orally Bioavailable JNK3 Inhibitors.
Journal, issue, pagesAcs Med. Chem. Lett., Vol. 12, Page 1546-1552, Year 2021
Publish dateSep 2, 2021 (structure data deposition date)
AuthorsFeng, Y. / Park, H. / Ryu, J.C. / Yoon, S.O.
External linksAcs Med. Chem. Lett. / PubMed:34676036
MethodsX-ray diffraction
Resolution2.11 Å
Structure data

PDB-7s1n:
N-Aromatic-Substituted Indazole Derivatives as Brain Penetrant and Orally Bioavailable JNK3 Inhibitors
Method: X-RAY DIFFRACTION / Resolution: 2.11 Å

Chemicals

ChemComp-86C:
4-[5-(2-chloro-6-fluoroanilino)-6-methyl-1H-pyrazolo[3,4-b]pyridin-1-yl]-N-(oxetan-3-yl)thiophene-2-carboxamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/Inhibitor / MAPK10 / JNK3 / Kinase Inhibitor / Alzheimers Diseases / Indazole / Azaindazole / Neurodegeneration / TRANSFERASE / TRANSFERASE-Inhibitor complex

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