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Title | Design, Synthesis, and Structure-Activity Relationship Optimization of Pyrazolopyrimidine Amide Inhibitors of Phosphoinositide 3-Kinase gamma (PI3K gamma ). |
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Journal, issue, pages | J. Med. Chem., Vol. 65, Page 1418-1444, Year 2022 |
Publish date | Jul 13, 2020 (structure data deposition date) |
Authors | Mata, G. / Miles, D.H. / Drew, S.L. / Fournier, J. / Lawson, K.V. / Mailyan, A.K. / Sharif, E.U. / Yan, X. / Beatty, J.W. / Banuelos, J. ...Mata, G. / Miles, D.H. / Drew, S.L. / Fournier, J. / Lawson, K.V. / Mailyan, A.K. / Sharif, E.U. / Yan, X. / Beatty, J.W. / Banuelos, J. / Chen, J. / Ginn, E. / Chen, A. / Gerrick, K.Y. / Pham, A.T. / Wong, K. / Soni, D. / Dhanota, P. / Shaqfeh, S.G. / Meleza, C. / Narasappa, N. / Singh, H. / Zhao, X. / Jin, L. / Schindler, U. / Walters, M.J. / Young, S.W. / Walker, N.P. / Leleti, M.R. / Powers, J.P. / Jeffrey, J.L. |
External links | J. Med. Chem. / PubMed:34672584 |
Methods | X-ray diffraction |
Resolution | 2.96 Å |
Structure data | PDB-6xrn: |
Chemicals | ChemComp-V84: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE inhibitor / Phosphoinositide 3-kinase gamma / inhibitor / AB610 / immunosuppression / cancer / Proteros / TRANSFERASE / TRANSFERASE-TRANSFERASE inhibitor complex |