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TitleDiscovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target Engagement.
Journal, issue, pagesJ. Med. Chem., Vol. 64, Page 15189-15213, Year 2021
Publish dateMar 16, 2021 (structure data deposition date)
AuthorsBarlaam, B. / De Savi, C. / Dishington, A. / Drew, L. / Ferguson, A.D. / Ferguson, D. / Gu, C. / Hande, S. / Hassall, L. / Hawkins, J. ...Barlaam, B. / De Savi, C. / Dishington, A. / Drew, L. / Ferguson, A.D. / Ferguson, D. / Gu, C. / Hande, S. / Hassall, L. / Hawkins, J. / Hird, A.W. / Holmes, J. / Lamb, M.L. / Lister, A.S. / McGuire, T.M. / Moore, J.E. / O'Connell, N. / Patel, A. / Pike, K.G. / Sarkar, U. / Shao, W. / Stead, D. / Varnes, J.G. / Vasbinder, M.M. / Wang, L. / Wu, L. / Xue, L. / Yang, B. / Yao, T.
External linksJ. Med. Chem. / PubMed:34647738
MethodsX-ray diffraction
Resolution2.81 Å
Structure data

PDB-7nwk:
Crystal structure of CDK9-Cyclin T1 bound by compound 6
Method: X-RAY DIFFRACTION / Resolution: 2.81 Å

Chemicals

ChemComp-UT5:
N-((1R,3R)-3-(7-(4-fluoro-2-methoxyphenyl)-3H-imidazo[4,5-b]pyridin-2-yl)cyclopentyl)acetamide

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / inhibitor / kinase

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