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-Structure paper
Title | Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations. |
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Journal, issue, pages | Mol. Cancer Ther., Vol. 20, Page 2446-2456, Year 2021 |
Publish date | Sep 30, 2021 (structure data deposition date) |
Authors | Murray, B.W. / Rogers, E. / Zhai, D. / Deng, W. / Chen, X. / Sprengeler, P.A. / Zhang, X. / Graber, A. / Reich, S.H. / Stopatschinskaja, S. ...Murray, B.W. / Rogers, E. / Zhai, D. / Deng, W. / Chen, X. / Sprengeler, P.A. / Zhang, X. / Graber, A. / Reich, S.H. / Stopatschinskaja, S. / Solomon, B. / Besse, B. / Drilon, A. |
External links | Mol. Cancer Ther. / PubMed:34625502 |
Methods | X-ray diffraction |
Resolution | 2.55 - 2.9 Å |
Structure data | PDB-7vkm: PDB-7vkn: PDB-7vko: |
Chemicals | ChemComp-HOH: ChemComp-7GI: ChemComp-SO4: |
Source |
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Keywords | TRANSFERASE / TRK / NTRK / macrocyclic inhibitor / drug resistance / repotrectinib |