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TitleStructures of Two Human Astrovirus Capsid/Neutralizing Antibody Complexes Reveal Distinct Epitopes and Inhibition of Virus Attachment to Cells.
Journal, issue, pagesJ. Virol., Vol. 96, Page e0141521-e0141521, Year 2022
Publish dateJul 21, 2021 (structure data deposition date)
AuthorsRicemeyer, L. / Aguilar-Hernandez, N. / Lopez, T. / Espinosa, R. / Lanning, S. / Mukherjee, S. / Cuellar, C. / Lopez, S. / Arias, C.F. / DuBois, R.M.
External linksJ. Virol. / PubMed:34613806
MethodsX-ray diffraction
Resolution2.05 - 2.65 Å
Structure data

PDB-7rk1:
Crystal structure of the human astrovirus serotype 8 capsid spike in complex with scFv 3E8, an astrovirus-neutralizing antibody, at 2.05-A resolution
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

PDB-7rk2:
Crystal structure of the human astrovirus serotype 8 capsid spike in complex with scFv 2D9, an astrovirus-neutralizing antibody, at 2.65-A resolution
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • human astrovirus-8
  • mus musculus (house mouse)
KeywordsVIRAL PROTEIN / capsid protein / icosahedral virus / single chain variable fragment

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