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TitleFragment-based lead discovery of indazole-based compounds as AXL kinase inhibitors.
Journal, issue, pagesBioorg. Med. Chem., Vol. 49, Page 116437-116437, Year 2021
Publish dateJan 19, 2021 (structure data deposition date)
AuthorsNg, P.S. / Foo, K. / Sim, S. / Wang, G. / Huang, C. / Tan, L.H. / Poulsen, A. / Liu, B. / Tee, D.H.Y. / Ahmad, N.H.B. ...Ng, P.S. / Foo, K. / Sim, S. / Wang, G. / Huang, C. / Tan, L.H. / Poulsen, A. / Liu, B. / Tee, D.H.Y. / Ahmad, N.H.B. / Wang, S. / Ke, Z. / Lee, M.A. / Kwek, Z.P. / Joy, J. / Anantharajan, J. / Baburajendran, N. / Pendharkar, V. / Manoharan, V. / Vuddagiri, S. / Sangthongpitag, K. / Hill, J. / Keller, T.H. / Hung, A.W.
External linksBioorg. Med. Chem. / PubMed:34600239
MethodsX-ray diffraction
Resolution3.146 Å
Structure data

PDB-7dxl:
Fragment-based Lead Discovery of Indazole-based Compounds as AXL Kinase Inhibitors
Method: X-RAY DIFFRACTION / Resolution: 3.146 Å

Chemicals

ChemComp-E56:
3-[4-[6-chloranyl-5-[[(3R)-pyrrolidin-3-yl]amino]-1H-indazol-3-yl]pyrazol-1-yl]benzenecarbonitrile

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / MER I650M kinase domain / AXL kinase inhibitors / Fragment based lead discovery / ONCOPROTEIN / TRANSFERASE / TRANSFERASE-TRANSFERASE INHIBITOR complex

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