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-Structure paper
Title | SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition. |
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Journal, issue, pages | Nat Commun, Vol. 12, Page 5779-5779, Year 2021 |
Publish date | Nov 1, 2020 (structure data deposition date) |
![]() | Ma, J. / Shi, Q. / Cui, G. / Sheng, H. / Botuyan, M.V. / Zhou, Y. / Yan, Y. / He, Y. / Wang, L. / Wang, Y. ...Ma, J. / Shi, Q. / Cui, G. / Sheng, H. / Botuyan, M.V. / Zhou, Y. / Yan, Y. / He, Y. / Wang, L. / Wang, Y. / Mer, G. / Ye, D. / Wang, C. / Huang, H. |
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Methods | X-ray diffraction |
Resolution | 3.4 Å |
Structure data | ![]() PDB-7klz: |
Chemicals | ![]() ChemComp-PO4: |
Source |
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![]() | PROTEIN BINDING / SPOP / Geminin / MATH domain / E3 ubiquitin ligase / DNA damage response / DNA replication |