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TitleAssembly defects of human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia.
Journal, issue, pagesNat Commun, Vol. 12, Page 5610-5610, Year 2021
Publish dateJun 4, 2020 (structure data deposition date)
AuthorsSekulovski, S. / Devant, P. / Panizza, S. / Gogakos, T. / Pitiriciu, A. / Heitmeier, K. / Ramsay, E.P. / Barth, M. / Schmidt, C. / Tuschl, T. ...Sekulovski, S. / Devant, P. / Panizza, S. / Gogakos, T. / Pitiriciu, A. / Heitmeier, K. / Ramsay, E.P. / Barth, M. / Schmidt, C. / Tuschl, T. / Baas, F. / Weitzer, S. / Martinez, J. / Trowitzsch, S.
External linksNat Commun / PubMed:34584079
MethodsX-ray diffraction
Resolution2.10001777636 Å
Structure data

PDB-6z9u:
Crystal structure of a TSEN15-34 heterodimer.
Method: X-RAY DIFFRACTION / Resolution: 2.10001777636 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSPLICING / tRNA splicing endonuclease / TSEN / precursor tRNA / pre-tRNA processing / neurodegenerative disorders / pontocerebellar hypoplasia

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