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-Structure paper
| Title | Identification of a PCSK9-LDLR disruptor peptide with in vivo function. |
|---|---|
| Journal, issue, pages | Cell Chem Biol, Vol. 29, Page 249-, Year 2022 |
| Publish date | Oct 12, 2020 (structure data deposition date) |
 Authors | Brousseau, M.E. / Clairmont, K.B. / Spraggon, G. / Flyer, A.N. / Golosov, A.A. / Grosche, P. / Amin, J. / Andre, J. / Burdick, D. / Caplan, S. ...Brousseau, M.E. / Clairmont, K.B. / Spraggon, G. / Flyer, A.N. / Golosov, A.A. / Grosche, P. / Amin, J. / Andre, J. / Burdick, D. / Caplan, S. / Chen, G. / Chopra, R. / Ames, L. / Dubiel, D. / Fan, L. / Gattlen, R. / Kelly-Sullivan, D. / Koch, A.W. / Lewis, I. / Li, J. / Liu, E. / Lubicka, D. / Marzinzik, A. / Nakajima, K. / Nettleton, D. / Ottl, J. / Pan, M. / Patel, T. / Perry, L. / Pickett, S. / Poirier, J. / Reid, P.C. / Pelle, X. / Seepersaud, M. / Subramanian, V. / Vera, V. / Xu, M. / Yang, L. / Yang, Q. / Yu, J. / Zhu, G. / Monovich, L.G. |
 External links | Cell Chem Biol / PubMed:34547225 |
| Methods | X-ray diffraction |
| Resolution | 2.45 - 2.8 Å |
| Structure data |  PDB-7kev:  PDB-7kfa: |
| Chemicals |  ChemComp-CA:  ChemComp-HOH: |
| Source |
|
 Keywords | LIPID TRANSPORT / HYDROLASE / PRO-PROTEIN CONVERTASE / CORONARY HEART DISEASE / HYPERCHOLESTEROLEMIA / LOW DENSITY LIPOPROTEIN RECEPTOR / AUTOCATALYTIC CLEAVAGE / CHOLESTEROL METABOLISM / DISEASE MUTATION / GLYCOPROTEIN / LIPID METABOLISM / PHOSPHORYLATION / PROTEASE / SECRETED / SERINE PROTEASE / STEROID METABOLISM / ZYMOGEN |
homo sapiens (human)