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Structure paper

TitleStructural insights into sphingosine-1-phosphate recognition and ligand selectivity of S1PR3-Gi signaling complexes.
Journal, issue, pagesCell Res, Vol. 32, Issue 2, Page 218-221, Year 2022
Publish dateSep 20, 2021
AuthorsChang Zhao / Lin Cheng / Wei Wang / Heli Wang / Yongbo Luo / Yuying Feng / Xuehui Wang / Hong Fu / Ye Cai / Shengyong Yang / Ping Fu / Wei Yan / Zhenhua Shao /
External linksCell Res / PubMed:34545189 / PubMed Central
MethodsEM (single particle)
Resolution3.1 - 3.2 Å
Structure data

31345

7ew2

EMDB-31345, PDB-7ew2:
Cryo-EM structure of pFTY720-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein
Method: EM (single particle) / Resolution: 3.1 Å

31346

7ew3

EMDB-31346, PDB-7ew3:
Cryo-EM structure of S1P-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein
Method: EM (single particle) / Resolution: 3.1 Å

31347

7ew4

EMDB-31347, PDB-7ew4:
Cryo-EM structure of CYM-5541-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein
Method: EM (single particle) / Resolution: 3.2 Å

Chemicals

ChemComp-J89:
(2~{S})-2-azanyl-4-(4-octylphenyl)-2-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]butan-1-ol

ChemComp-S1P:
(2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate

ChemComp-PLM:
PALMITIC ACID

ChemComp-JF9:
N,N-dicyclohexyl-5-cyclopropyl-1,2-oxazole-3-carboxamide

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / Complex / Agonist

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