タイトル | Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1. |
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ジャーナル・号・ページ | Commun Biol, Vol. 4, Page 1105-1105, Year 2021 |
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掲載日 | 2020年12月3日 (構造データの登録日) |
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著者 | Patel, O. / Roy, M.J. / Kropp, A. / Hardy, J.M. / Dai, W. / Lucet, I.S. |
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リンク | Commun Biol / PubMed:34545159 |
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手法 | X線回折 |
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解像度 | 2.5 - 3.1 Å |
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構造データ | PDB-7kx6: Crystal structure of DCLK1-KD in complex with XMD8-85 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-7kx8: Crystal structure of DCLK1-Cter in complex with FMF-03-055-1 手法: X-RAY DIFFRACTION / 解像度: 3.1 Å PDB-7kxw: Crystal structure of DCLK1-KD in complex with DCLK1-IN-1 手法: X-RAY DIFFRACTION / 解像度: 3.002 Å |
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化合物 | ChemComp-X7Y: 2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one
ChemComp-X8J: 5-ethyl-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}-11-methyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one
ChemComp-XBD: 2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}-11-methyl-5-(2,2,2-trifluoroethyl)-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one
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由来 | homo sapiens (ヒト)
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キーワード | TRANSFERASE / KINASE / DOUBLECORTIN-LIKE |
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