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TitlePantothenate kinase activation relieves coenzyme A sequestration and improves mitochondrial function in mice with propionic acidemia.
Journal, issue, pagesSci Transl Med, Vol. 13, Page eabf5965-eabf5965, Year 2021
Publish dateJun 20, 2019 (structure data deposition date)
AuthorsSubramanian, C. / Frank, M.W. / Tangallapally, R. / Yun, M.K. / Edwards, A. / White, S.W. / Lee, R.E. / Rock, C.O. / Jackowski, S.
External linksSci Transl Med / PubMed:34524863
MethodsX-ray diffraction
Resolution1.6 Å
Structure data

PDB-6pe6:
PANK3 complex structure with compound PZ-3022
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-ODG:
6-{4-[(4-cyclopropylphenyl)acetyl]piperazin-1-yl}pyridazine-3-carbonitrile

ChemComp-ANP:
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP, energy-carrying molecule analogue*YM

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / PANK / Substrate / Complex / Pantothenate kinase

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