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TitleDiscovery of ZN-c3, a Highly Potent and Selective Wee1 Inhibitor Undergoing Evaluation in Clinical Trials for the Treatment of Cancer.
Journal, issue, pagesJ. Med. Chem., Vol. 64, Page 13004-13024, Year 2021
Publish dateJun 2, 2021 (structure data deposition date)
AuthorsHuang, P.Q. / Boren, B.C. / Hegde, S.G. / Liu, H. / Unni, A.K. / Abraham, S. / Hopkins, C.D. / Paliwal, S. / Samatar, A.A. / Li, J. / Bunker, K.D.
External linksJ. Med. Chem. / PubMed:34423975
MethodsX-ray diffraction
Resolution2.65 Å
Structure data

PDB-7n3u:
Crystal structure of human WEE1 kinase domain in complex with ZN-c3
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

Chemicals

ChemComp-05J:
1-[(7R)-7-ethyl-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / phosphotransferase / protein kinase-like / alpha and beta proteins (a+b) / cell division

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