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Structure paper

TitleStructural features of Cryptococcus neoformans bifunctional GAR/AIR synthetase may present novel antifungal drug targets.
Journal, issue, pagesJ. Biol. Chem., Vol. 297, Page 101091-101091, Year 2021
Publish dateFeb 26, 2021 (structure data deposition date)
AuthorsChua, S.M.H. / Wizrah, M.S.I. / Luo, Z. / Lim, B.Y.J. / Kappler, U. / Kobe, B. / Fraser, J.A.
External linksJ. Biol. Chem. / PubMed:34416230
MethodsX-ray diffraction
Resolution2 - 2.24 Å
Structure data

PDB-7lvo:
Cryptococcus neoformans GAR synthetase
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-7lvp:
Cryptococcus neoformans AIR synthetase
Method: X-RAY DIFFRACTION / Resolution: 2.24 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-SIN:
SUCCINIC ACID

ChemComp-PO4:
PHOSPHATE ION

ChemComp-GLY:
GLYCINE

Source
  • cryptococcus neoformans var. grubii serotype a (fungus)
KeywordsBIOSYNTHETIC PROTEIN / LIGASE / GAR synthetase / phosphoribosyl-glycinamide synthetase / phosphoribosylglycinamide synthetase / AIR synthetase / phosphoribosyl-aminoimidazole synthetase / phosphoribosylaminoimidazole synthetase

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