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-Structure paper
Title | Optimization of Naphthyridones into Selective TATA-Binding Protein Associated Factor 1 (TAF1) Bromodomain Inhibitors. |
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Journal, issue, pages | Acs Med. Chem. Lett., Vol. 12, Page 1308-1317, Year 2021 |
Publish date | Jul 13, 2021 (structure data deposition date) |
![]() | Clegg, M.A. / Theodoulou, N.H. / Bamborough, P. / Chung, C.W. / Craggs, P.D. / Demont, E.H. / Gordon, L.J. / Liwicki, G.M. / Phillipou, A. / Tomkinson, N.C.O. ...Clegg, M.A. / Theodoulou, N.H. / Bamborough, P. / Chung, C.W. / Craggs, P.D. / Demont, E.H. / Gordon, L.J. / Liwicki, G.M. / Phillipou, A. / Tomkinson, N.C.O. / Prinjha, R.K. / Humphreys, P.G. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 2.17 Å |
Structure data | ![]() PDB-7p4s: |
Chemicals | ![]() ChemComp-5LV: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSCRIPTION / second bromodomain of TAF1 / inhibitor-bound / complex |