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Structure paper

TitleTargeted Degradation of the Oncogenic Phosphatase SHP2.
Journal, issue, pagesBiochemistry, Vol. 60, Page 2593-2609, Year 2021
Publish dateJul 8, 2021 (structure data deposition date)
AuthorsVemulapalli, V. / Donovan, K.A. / Seegar, T.C.M. / Rogers, J.M. / Bae, M. / Lumpkin, R.J. / Cao, R. / Henke, M.T. / Ray, S.S. / Fischer, E.S. ...Vemulapalli, V. / Donovan, K.A. / Seegar, T.C.M. / Rogers, J.M. / Bae, M. / Lumpkin, R.J. / Cao, R. / Henke, M.T. / Ray, S.S. / Fischer, E.S. / Cuny, G.D. / Blacklow, S.C.
External linksBiochemistry / PubMed:34411482
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-7rct:
Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor RMC-4550
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-4Q4:
{3-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-6-(2,3-dichlorophenyl)-5-methylpyrazin-2-yl}methanol

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / SHP2 RMC-4550 phosphatase

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