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TitleReconstitution and Structural Analysis of a HECT Ligase-Ubiquitin Complex via an Activity-Based Probe.
Journal, issue, pagesAcs Chem. Biol., Vol. 16, Page 1615-1621, Year 2021
Publish dateJan 31, 2020 (structure data deposition date)
AuthorsNair, R.M. / Seenivasan, A. / Liu, B. / Chen, D. / Lowe, E.D. / Lorenz, S.
External linksAcs Chem. Biol. / PubMed:34403242
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-6xz1:
Conjugate of the HECT domain of HUWE1 with ubiquitin
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-PO4:
PHOSPHATE ION

ChemComp-AYE:
prop-2-en-1-amine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLIGASE / ubiquitin ligase / E3 enzyme / ubiquitin-propargylamide / activity-based probe

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