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TitleStructure of autoinhibited Akt1 reveals mechanism of PIP 3 -mediated activation.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 118, Year 2021
Publish dateOct 16, 2020 (structure data deposition date)
AuthorsTruebestein, L. / Hornegger, H. / Anrather, D. / Hartl, M. / Fleming, K.D. / Stariha, J.T.B. / Pardon, E. / Steyaert, J. / Burke, J.E. / Leonard, T.A.
External linksProc. Natl. Acad. Sci. USA / PubMed:34385319
MethodsX-ray diffraction
Resolution2.05 Å
Structure data

PDB-7apj:
Structure of autoinhibited Akt1 reveals mechanism of PIP3-mediated activation
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • danio rerio (zebrafish)
  • lama glama (llama)
KeywordsSIGNALING PROTEIN / kinase / autoinhibition / lipid / membrane / PIP3 / Akt

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