タイトル | Design, synthesis and evaluation of side-chain hydroxylated derivatives of lithocholic acid as potent agonists of the vitamin D receptor (VDR). |
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ジャーナル・号・ページ | Bioorg. Chem., Vol. 115, Page 105202-105202, Year 2021 |
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掲載日 | 2021年6月23日 (構造データの登録日) |
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著者 | Gonzalez, C.M. / Gaikwad, S. / Lasanta, G. / Loureiro, J. / Nilsson, N. / Peluso-Iltis, C. / Rochel, N. / Mourino, A. |
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リンク | Bioorg. Chem. / PubMed:34339974 |
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手法 | X線回折 |
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解像度 | 2 - 2.2 Å |
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構造データ | PDB-7oxz: VDR complex with a side-chain hydroxylated derivative of lithocholic acid 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-7oy4: VDR complex of a side-chain hydroxylated derivatives of lithocholic acid 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å |
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化合物 | ChemComp-2UI: (3R,6R)-6-[(3R,5R,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3-(2-methyl-2-oxidanyl-propyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]heptane-1,3-diol
ChemComp-2WV: (3S,6R)-6-[(3R,5R,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3-(2-methyl-2-oxidanyl-propyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]heptane-1,3-diol
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由来 | ![](img/tx_fish.gif) danio rerio (ゼブラフィッシュ) homo sapiens (ヒト)
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キーワード | TRANSCRIPTION / nuclear recptor / agonist |
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