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-Structure paper
Title | ASTX029, a Novel Dual-mechanism ERK Inhibitor, Modulates Both the Phosphorylation and Catalytic Activity of ERK. |
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Journal, issue, pages | Mol. Cancer Ther., Vol. 20, Page 1757-1768, Year 2021 |
Publish date | Nov 3, 2020 (structure data deposition date) |
![]() | Munck, J.M. / Berdini, V. / Bevan, L. / Brothwood, J.L. / Castro, J. / Courtin, A. / East, C. / Ferraldeschi, R. / Heightman, T.D. / Hindley, C.J. ...Munck, J.M. / Berdini, V. / Bevan, L. / Brothwood, J.L. / Castro, J. / Courtin, A. / East, C. / Ferraldeschi, R. / Heightman, T.D. / Hindley, C.J. / Kucia-Tran, J. / Lyons, J.F. / Martins, V. / Muench, S. / Murray, C.W. / Norton, D. / O'Reilly, M. / Reader, M. / Rees, D.C. / Rich, S.J. / Richardson, C.J. / Shah, A.D. / Stanczuk, L. / Thompson, N.T. / Wilsher, N.E. / Woolford, A.J. / Wallis, N.G. |
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Methods | X-ray diffraction |
Resolution | 1.76 Å |
Structure data | ![]() PDB-7auv: |
Chemicals | ![]() ChemComp-SO4: ![]() ChemComp-DMS: ![]() ChemComp-RYW: ![]() ChemComp-HOH: |
Source |
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